SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
SRPIN340
CAS: 218156-96-8
Molecular Formula: C18H18F3N3O
SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide - Names and Identifiers
SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide - Physico-chemical Properties
| Molecular Formula | C18H18F3N3O |
| Molar Mass | 349.35 |
| Density | 1.306±0.06 g/cm3(Predicted) |
| Boling Point | 395.9±42.0 °C(Predicted) |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.09±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Use | SRPIN340 is a selective SRPK inhibitor, acting on SRPK1, Ki is 0.89 μM, and has no significant inhibitory activity on more than 140 other kinases. |
| In vitro study | SRPIN340 inhibits SR phosphorylation in Flp-In293 of cells by SRPK and promotes degradation of SRp75 in a dose-dependent manner, followed by inhibition of HIV production. SRPIN340 at 5 mg/ml did not cause abnormalities in chromosome structure and chromosome number in CHO cells. SRPIN340 dose-dependently inhibits the expression of HCV subgenomic replication and HCV-JFH1 clonal replication in vitro. |
| In vivo study | SRPIN340 dose-dependently inhibited the formation of CNV in vivo. SRPIN340 significantly reduced the protein levels of VEGF,MCP-1,ICAM-1, thereby inhibiting macrophage infiltration. |
SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.862 ml | 14.312 ml | 28.625 ml |
| 5 mM | 0.572 ml | 2.862 ml | 5.725 ml |
| 10 mM | 0.286 ml | 1.431 ml | 2.862 ml |
| 5 mM | 0.057 ml | 0.286 ml | 0.572 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: SRPIN340 Visit Supplier Webpage Request for quotationCAS: 218156-96-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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